NFL Week 15: The best photos

The Jacksonville Jaguars observe a moment of silence to honor the victims of the Connecticut school shooting before their game against the Miami Dolphins at Sun Life Stadium on Sunday, December 16. Check out the action from Week 15 of the NFL and then look back at the best photos from Week 14.

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First funerals set for Conn. shooting victims

Nov. 13, 2012 photo provided by the family via The Washington Post shows Noah Pozner, 6 / AP/Family Photo

NEWTOWN, Conn. The Connecticut Funeral Directors Association has announced that funerals have been scheduled for seven of the Connecticut school shooting victims.

Services for 6-year-olds Noah Pozner and Jack Pinto are being planned for Monday.

The funeral for 6-year-old Jessica Rekos is Tuesday.

On Wednesday, there will be funerals for 7-year-old Daniel Barden and 27-year-old teacher Victoria Soto.

19 Photos

Victims of Conn. school shooting

Services will be held on Thursday for 6-year-old Catherine Hubbard.

A private service has been planned for 6-year-old Dylan Hockley. No date was announced.

A spokesman for the local diocese, Brian Wallace, said it had not been asked yet to provide funerals for gunman Adam Lanza or his mother. Police say he shot her to death before heading to the Sandy Hook Elementary School and going on his rampage.

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'We Can't Tolerate This Anymore,' Obama Says

President Barack Obama said at an interfaith prayer service in this mourning community this evening that the country is "left with some hard questions" if it is to curb a rising trend in gun violence, such as the shooting spree Friday at Newtown's Sandy Hook Elementary School.

After consoling victims' families in classrooms at Newtown High School, the president said he would do everything in his power to "engage" a dialogue with Americans, including law enforcement and mental health professionals, because "we can't tolerate this anymore. These tragedies must end. And to end them we must change."

Mandel Ngan/AFP/Getty Images

President Obama: 'Newtown You Are Not Alone' Watch Video

Sandy Hook Elementary Shooting: Remembering the Victims Watch Video

The president was not specific about what he thought would be necessary and did not even use the word "gun" in his remarks, but his speech was widely perceived as prelude to a call for more regulations and restrictions on the availability of firearms.

The grieving small town hosted the memorial service this evening as the the nation pieces together the circumstances that led to a gunman taking 26 lives Friday at the community's Sandy Hook Elementary School, most first graders.

"Someone once described the joy and anxiety of parenthood as the equivalent of having your heart outside your body all of the time, walking around," he said, speaking of the joys and fears of raising children.

"So it comes as a shock at a certain point when you realize no matter how much you love these kids you can't do it by yourself," he continued. "That this job of protecting kids and teaching them well is something we can only do together, with the help of friends and neighbors, with the help of a community, and the help of a nation."

CLICK HERE for Full Coverage of the Tragedy at Sandy Hook

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How human biology can prevent drug deaths

Thousands of people die from adverse effects of medicines that have been tested on animals. There is a better way, say geneticist Kathy Archibald and pharmacologist Robert Coleman

ADVERSE drug reactions are a major cause of death, killing 197,000 people annually in the European Union and upwards of 100,000 in the US. Little coverage is given to such grim statistics by governments or pharmaceutical companies, so patients and their doctors are not primed to be as vigilant as they should be, and adverse drug reactions (ADRs) remain seriously under-recognised and under-reported.

The €5.88-million EU-ADR project, which published its final report in October, showed that it is possible to spot these reactions earlier by applying data-mining techniques to electronic health records. These techniques could, for example, have detected the cardiovascular risk signals of arthritis drug Vioxx three years before the drug was withdrawn in 2004 - saving many tens of thousands of lives. But invaluable as such systems are, it would be even better to detect risk signals before a drug reaches humans, thus saving even more lives.

Currently, 92 per cent of new drugs fail clinical trials, even though they have successfully passed animal tests. This is mostly because of toxicity, which can be serious and even fatal for the people taking part in the trials. For example, in 2006, six people enrolled in a UK trial of the drug TGN1412 were hospitalised after developing multiple organ failure. Many clinical trials are now conducted in India, where, according to India's Tribune newspaper, at least 1725 people died in drug trials between 2007 and 2011. Clearly, there is an urgent need for better methods to predict the safety of medicines for patients as well as volunteers in clinical trials.

At the patient safety charity, Safer Medicines, we believe this goal is most likely to be achieved through a greatly increased focus on human, rather than animal, biology in preclinical drugs tests. New tests based on human biology can predict many adverse reactions that animal tests fail to do, and could, for example, have detected the risk signals produced by Vioxx, which in animal studies appeared to be safe, and even beneficial to the heart.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed "patient in a dish"); "body on a chip" devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy. Then there are the more humble but no less valuable studies in ethically donated "waste" tissue.

These innovations promise precious insights into the functioning of the integrated human system. Many are already commercially available, but they are not being embraced with the enthusiasm they merit.

Pharmaceutical companies would make much greater use of them if governments encouraged it, but inflexible requirements for animal tests is a major deterrent. Ever since the thalidomide birth-defects tragedy, animal testing has been enshrined in law worldwide, despite the irony that more animal testing would not have prevented the release of thalidomide, because the drug harms very few species.

So how well have animal tests protected us? Many studies have calculated the ability of animal tests to predict adverse reactions to be at or below 50 per cent. In 2008, a study in Theriogenology (vol 69, p 2) concluded: "On average, the extrapolated results from studies using tens of millions of animals fail to accurately predict human responses." And a recent study in Regulatory Toxicology and Pharmacology (vol 64, p 345) shows that animal tests missed 81 per cent of the serious side effects of 43 drugs that went on to harm patients.

It is hard to understand why governments defend a system with such a poor record, or why they are dismissive of new technologies that promise increased patient safety while decreasing the time and cost of drug development, not to mention the savings to healthcare systems from fewer adverse drug reactions. Proposals to compare human-based tests with animal-based approaches have been strongly supported by members of the UK parliament. The Early Day Motions they signed were among the most-signed of all parliamentary motions between 2005 and 2006, 2008 and 2009, and 2010 and 2012.

Safer Medicines has put these concerns to the UK Department of Health and the prime minister - to be told that "human biology-based tests are not better able to predict adverse drug reactions in humans than animal tests".

It is a tragedy that so many suffer or die through the use of inadequately tested drugs when tests based on human biology are readily available. Yet governments continue to mandate animal tests, despite the lack of a formal demonstration of fitness for purpose, and a growing global realisation among scientists that animal toxicity tests are inadequate and must be replaced.

In its 2007 report, Toxicity Testing in the 21st Century: A Vision and a Strategy, the US National Research Council called for the replacement of animal tests: "The vision for toxicity testing in the 21st century articulated here represents a paradigm shift from the use of experimental animals... toward the use of more efficient in vitro tests and computational techniques." To its credit, the US government is at least working on initiatives to hasten this. The UK government, however, still denies there is a problem. How many must die before it listens?

Kathy Archibald is director of the Safer Medicines Trust. She is a geneticist who worked in the pharmaceutical industry.

Robert Coleman is a pharmacologist with pharmaceutical industry experience. He is now a drug discovery consultant and adviser to the trust

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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China commentary urges policy shift as Japan votes

BEIJING: China's state media on Sunday urged Japan to seek a post-election foreign policy that will improve relations with its neighbours, as Japanese voted in a poll likely to bring in a more hawkish administration.

It came just days after Beijing's latest effort to bolster its claim to disputed islands at the centre of a fierce row with Tokyo, by submitting to the United Nations information on the outer limits of its continental shelf.

The state Xinhua news agency commentary called on whichever party comes out on top to "devise its foreign policy with a long-term and pragmatic" view so Japan can "repair its strained ties with neighbours".

Ties between the Asian giants have soured in recent months due to the row over the East China Sea islands, which are controlled by Tokyo but claimed by Beijing.

Commentators believe the dispute has given a boost to right-wingers in Japan, where the conservative Liberal Democratic Party is expected to defeat the ruling Democratic Party of Japan in Sunday's elections for parliament's lower house.

Shinzo Abe, LDP president and the likely next premier, has said he would take a harder line on foreign policy and revitalise ties with the United States.

The Xinhua commentary cited a "troubling sign" that some Japanese political parties are advocating a hardline over the country's territorial disputes.

"These policies, if carried out, will surely further sour Japan's relations with its neighbors and even increase political and military risks in the region," it said.

China's foreign ministry said on Friday that Beijing told the UN in its submission that geographical characteristics "show that the continental shelf of China in the East China Sea extends to the Okinawa Trough, an important geographical unit with remarkable partition."

Such a definition of China's continental shelf would include the disputed islands. Japan's Okinawan islands lie to the east of the trough.

The escalation in the dispute over the uninhabited islands, known as Diaoyu in China and Senkaku in Japan, was triggered when the Japanese government in September purchased some of the islands from the private Japanese owner.

The purchase triggered sometimes-violent anti-Japanese riots in China.

Ships from Japan, China and Taiwan -- which also claims the island -- have engaged in stand-offs and last week Japan scrambled fighter jets after a Chinese state-owned plane flew over the area.

- AFP/xq

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Pearlman: I think Bobby Petrino is slime

Bobby Petrino was named head coach at Western Kentucky, months after being embroiled in scandal at University of Arkansas

STORY HIGHLIGHTS

• Bobby Petrino was named the new football coach at Western Kentucky this week


• Hiring came just months after he was fired from Arkansas amid scandal


• Jeff Pearlman says, sadly, this is no surprise in big-time college sports


• He says the vast majority of players are ultimately hurt by the behavior of coaches and administrators

Editor's note: Jeff Pearlman is the author of 'Sweetness: The Enigmatic Life of Walter Payton.' He blogs at jeffpearlman.com. Follow him on Twitter.

(CNN) -- I have a dog named Norma.

She is a small beige cockapoo who barks at the mailman.

I would not trust Bobby Petrino to watch her.

Jeff Pearlman

I also would not trust Bobby Petrino to take my car in for a tire change. I would not trust Bobby Petrino to deposit my Aunt Ruth's Social Security check. I wouldn't trust him to clean my bowling ball, shop for a Christmas ham, change a twenty for two tens, tell me the time or recite the proper lyrics to Blind Melon's "No Rain."

This is not because I am a particularly untrusting person.

No, it's because I think Bobby Petrino is slime.

In case you missed the news, two days ago Western Kentucky University held a press conference to announce that Petrino, undeniably one of the nation's elite football minds, had agreed to a four-year, $850,000 per year deal to take over the Hilltoppers.

With nearly 400 giddy sports fanatics in attendance, Petrino, standing alongside Todd Stewart, the school's athletic director, spoke of honor and loyalty and love and redemption. The ensuing press release, issued by Western Kentucky's sports information department, was straight out of Disney: 101. It made Petrino sound like a cross between Vince Lombardi, Martin Luther King and Gandhi; God's gift to young men seeking to better themselves.

Petrino fired as Arkansas head football coach

What it failed to mention—and what the school desperately wants everyone to fail to mention—is that Petrino may well be the least ethically whole man in the, ahem, ethically whole-deprived world of Division I collegiate sports.

Why, it was only seven months ago that Petrino, at the time the University of Arkansas' head coach, was riding his motorcycle when he crashed along Highway 16 near Crosses, Arkansas.

When asked by school officials to explain what had happened, he failed to mention that, eh, also on the bike was Jessica Dorrell, a 26-year-old former Razorbacks volleyball player who worked as the student-athlete development coordinator for the football program. It turned out that Petrino, a married father of four, was not only having an affair with Dorrell (who was engaged at the time), but was a key voice on the board that hired her for the position when she wasn't even remotely qualified.

During an ensuing university investigation, it was determined that Petrino made a previously undisclosed $20,000 cash gift to Dorrell as a Christmas present.

Ho, ho, ho.

To his credit, Jeff Long, the school's athletic director, defied the wishes of every pigskin-blinded Razorback fan and fired Petrino. In a statement, he rightly wrote that, "all of these facts, individually and collectively, are clearly contrary to character and responsibilities of the person occupying the position of the Head Football Coach—an individual who should serve as a role model and a leader for our student-athlete."

Now, ethics and morals and character be damned, Bobby Petrino has returned, spewing off nonsense about second chances (Ever notice how garbage men and bus drivers rarely get the second chances we are all—according to fallen athletic figures—rightly afforded as Americans?) and learning from mistakes and making things right.

Western Kentucky, a school with mediocre athletics and apparently, sub-mediocre standards, has turned to a person who lied to his last employer about the nature of an accident involving the mistress he allegedly hired to a university position she was unqualified to hold. Please, if you must, take a second to read that again. And again. And again.

Bobby Petrino, holder of a Ph.D. in the Deceptive Arts (he also ditched the University of Louisville shortly after signing a long-term extension in 2007, and quit as coach of the Atlanta Falcons 13 game into his first season later that year. He informed his players via a note atop their lockers), will be the one charged with teaching the 17- and 18-year-old boys who decide to come to Bowling Green about not merely football, but life. He will be their guide. Their compass. Their role model.

Bobby Petrino and social media prove a bad mix

Sadly, in the world of Division I sports, such is far from surprising. This has been a year unlike any other; one where the virtues of greed and the color of green don't merely cloak big-time college athletics, but control them. In case you haven't noticed, we are in the midst of a dizzying, nauseating game of Conference Jump, where colleges and universities—once determined to maintain geographic rivals in order to limit student travel—have lost their collective minds.

The University of Maryland, a charter member of the ACC, is headed for the Big Ten. The Big East—formerly a power conference featuring the likes of Syracuse, Georgetown, St. John's and Connecticut—has added Boise State, San Diego State, Memphis, Houston, Southern Methodist and Navy. Idaho moved from the WAC to the Big Sky, Middle Tennessee State and Florida Atlantic went to Conference USA, the University of Denver—a member of the WAC for approximately 27 minutes—joined the Summit League. Which, to be honest, I didn't even know existed.

Rest assured, none of these moves (literally, nary a one) were conducted with the best interests of so-called student-athletes in mind. New conferences tend to offer increased payouts, increased merchandising opportunities, increased exposure and increased opportunities to build a new stadium—one with 80,000 seats, 100 luxury boxes, $20 million naming rights, $9 hot dogs and the perfect spot for ESPN to broadcast its Home Depot pregame show.

Why, within 24 hours of quarterback Johnny Manziel winning the Heisman Trophy, Texas A&M was hawking Heisman T-shirts for $24 on its website (Or, for a mere $54.98, one can purchase his No. 2 jersey).

Percentage of the dough that winds up in Manziel's pocket? Zero.

After another spectacular exit, Petrino eyes football return

That, really, is the rub of it all; of Petrino's crabgrass-like revival; of coaches bounding from one job for another (even as players can only do so after sitting out a year); of Rutgers moving west and San Diego State moving east and athletic department officials moving on up (to a penthouse apartment in the sky); of $54.98 jerseys.

It's the athletes ultimately getting screwed.

Sure, for the 0.5% of Division I football players who wind up in the NFL, the deal is a sweet one. The other 99.5%, however, are mere pawns, sold a dizzying narrative of glory and fame and lifelong achievement, but, more often than not, left uneducated, unfulfilled and physically battered.

They are told a coach will be with them for four years—then watch as said figure takes a $2 million gig elsewhere but, hey, only because it was right for him and his family.

They are told they will receive a great education, then find themselves stuck on a six-hour flight from California to Newark, New Jersey. They are told that these will be the greatest years of their life, that the college experience is a special one, that only the highest of standards exist.

Then they meet their new coach: Bobby Petrino.

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The opinions expressed in this commentary are solely those of Jeff Pearlman.

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Conn. dad recalls loving, creative 6-year-old

NEWTOWN, Conn. Fighting back tears and struggling to catch his breath, the father of a 6-year-old gunned down in Friday's school shooting in Connecticut told the world about a little girl who loved to draw and was always smiling, and he also reserved surprising words of sympathy for the gunman.

Robbie Parker's daughter Emilie was among the 20 children who died in the one of the worst attacks on schoolchildren in U.S. history. He was one of the first parents to speak publicly about their loss.

"She was beautiful. She was blond. She was always smiling," he said.

Parker spoke to reporters not long after police released the names and ages of the victims, a simple document that told a horrifying story of loss.

He expressed no animosity, said he was not mad and offered sympathy for family of the man who killed 26 people and himself.

To the man's family, he said, "I can't imagine how hard this experience must be for you."

He said he struggled to explain the death to Emilie's two siblings, 3 and 4.

"They seem to get the fact that they have somebody they're going to miss very much," he said.

Parker said his daughter loved to try new things — except for new food. And she was quick to cheer up those in need.

36 Photos

Vigils for Conn. school shooting victims

"She never missed an opportunity to draw a picture or make a card for those she around her," he said.

The world is a better place because Emilie was in it, he said.

"I'm so blessed to be her dad," he said.

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Conn. Victim's Father Remembers 'Loving' Daughter

(Image credit: Emilie Parker Fund/Facebook)

Emilie Parker, the little girl with the blond hair and bright blue eyes, would have been one of the first to comfort her classmates at Sandy Hook Elementary School, had a gunman’s bullets not claimed her life, her father said.

“My daughter Emilie would be one of the first ones to be standing and giving support to all the victims because that’s the kind of kid she is,” her father, Robbie Parker said as he fought back tears, telling the world about his “bright, creative and loving” daughter who was one of the 20 young victims in the Newtown, Conn., shooting.

“She always had something kind to say about anybody,” her father said.  ”We find comfort reflecting on the incredible person Emilie was and how many lives she was able to touch.”

Emilie, 6, was helping teach her younger sisters to read and make things, and she was the little girls would go to for comfort, he said.

“They looked up to her,” Parker said.

READ: Complete List of Sandy Hook Victims

Parker moved his wife and three daughters to Newtown eight months ago after accepting a job as  a physician’s assistant at Danbury Hospital. He said Emilie, his oldest daughter, seemed to have adjusted well to her new school, and he was very happy with the school, too.

“I love the people at the school. I love Emilie’s teacher and the classmates we were able to get to know,” he said.

      (Image Credit: Alex von Kleydorff/AP Photo)

The family dealt with another tragic loss in October when Emilie lost her grandfather in an accident.

“[This] has been a topic that has been discussed in our family in the past couple of  months,” Parker said. “[My daughters ages 3 and 4] seem to get the idea that there’s somebody who they will miss very much.”

Emilie, a budding artist who carried her markers and pencils everywhere, paid tribute to her grandfather by slipping a special card she had drawn into his casket, Parker said.  It was something she frequently did to lift the spirits of others.

“I can’t count the number of times Emilie would find someone feeling sad or frustrated and would make people a card,” Parker said. “She was an exceptional artist.”

The girl who was remembered as “always willing to try new things, other than food” was learning Portuguese from her father, who speaks the language.

(Image Credit: Emilie Parker Fund/Facebook)

On Friday morning, Emilie woke up before her father left for his job and exchanged a few sentences with him in the language.

“She told me good morning and asked how I was doing,” Parker said. “She said she loved me, I gave her a kiss and I was out the door.”

Parker found out about the shooting while on lockdown in Danbury Hospital and found a television for the latest news.

“I didn’t think it was that big of deal at first,” he said. “With the first reports coming in, it didn’t sound like it was going to be as tragic as it was. That’s kind of what it was like for us.”

CLICK HERE for full coverage of the Sandy Hook shooting.

Parker said he knows that God can’t take away free will and would have been unable to stop the Sandy Hook shooting. While gunman Adam Lanza used his free agency to take innocent lives, Parker said he plans to use his in a positive way.

“I’m not mad because I have my  [free] agency to use this event to do whatever I can to make sure my family and my wife and my daughters are taken care [of],” he said. “And if there’s anything I can do to help to anyone at any time at anywhere, I’m free to do that.”

(Image credit: Emilie Parker Fund/Facebook)

Friday night, hours after he learned of his daughter’s death, Parker said he spoke at his church.

“I don’t know how to get through something like this. My wife and I don’t understand how to process all of this,” he said today. “We find strength in our religion and in our faith and in our family. ”

“It’s a horrific tragedy and I want everyone to know our hearts and prayers go out to them. This includes the family of the shooter. I can’t imagine how hard this experience must be for you and I want you to know our family … love and support goes out to you as well.”

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Zebrafish made to grow pre-hands instead of fins

PERHAPS the little fish embryo shown here is dancing a jig because it has just discovered that it has legs instead of fins. Fossils show that limbs evolved from fins, but a new study shows how it may have happened, live in the lab.

Fernando Casares of the Spanish National Research Council and his colleagues injected zebrafish with the hoxd13 gene from a mouse. The protein that the gene codes for controls the development of autopods, a precursor to hands, feet and paws.

Zebrafish naturally carry hoxd13 but produce less of the protein than tetrapods - all four-limbed vertebrates and birds - do. Casares and his colleagues hoped that by injecting extra copies of the gene into the zebrafish embryos, some of their cells would make more of the protein.

One full day later, all of those fish whose cells had taken up the gene began to develop autopods instead of fins. They carried on growing for four days but then died (Cell, DOI: 10.1016/j.devcel.2012.10.015).

"Of course, we haven't been able to grow hands," says Casares. He speculates that hundreds of millions of years ago, the ancestors of tetrapods began expressing more hoxd13 for some reason and that this could have allowed them to evolve autopods.

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India PM says reforms steps "only the beginning"

NEW DELHI: India's premier Manmohan Singh said on Saturday his government's new reforms to spur the economy were "only the beginning", while lashing out at the "excessive pessimism" that he said is hurting growth.

Singh's government has initiated a string of reforms to further open up sectors such as retail, insurance and aviation to foreign investment as it seeks to kickstart growth before facing voters in 2014 elections.

"The steps we have taken are only the beginning of a process to revive our economy and take it back to its trend growth rate of eight to nine per cent," Singh told an audience of corporate leaders in New Delhi.

"Our government has acted to reverse the cycle of negative expectations and stimulate investment," he said.

But "excessive pessimism at home" and a "less supportive" global environment have made the Congress-led government's task of reviving the flagging economy much tougher, he added.

India's economic growth slipped to a near-decade low of 6.5 per cent in the last fiscal year and is expected to fall to around 5.5 per cent this year.

While much of the world would envy such a growth rate, the pace is not enough for India which says it needs close to double-digit expansion to substantially reduce crushing poverty.

"Even as we make our growth process more inclusive, we cannot lower our guard in pursuing policies that restore growth momentum to the economy," Singh said.

He said the government had taken tough decisions to rekindle investor enthusiasm and rein in the ballooning fiscal deficit which has brought warnings of a downgrade from global ratings agencies.

"Some of the decisions we have taken were politically difficult and the naysayers and the cynics have tried to halt us in our tracks," Singh said.

Parties that have been fighting the reforms, including the main opposition Hindu nationalist Bharatiya Janata Party, "are either ignorant or constrained by outdated ideologies", Singh said.

Last week the fragile minority coalition government succeeded in winning approval for its move to allow in foreign supermarkets -- a flagship of its renewed reform agenda -- despite fierce political opposition.

- AFP/xq

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